Many researchers are looking into whether Resveratrol has the cancer-fighting properties that many people say it does.  At first glance, it seems almost impossible for a simple compound that is found in red wine, grapes, and other fruits/legumes would have significant cancer-fighting properties.  Resveratrol, however, is quickly exceeding even the most optimistic expectations.

Studies have shown that, at least in the laboratory, Resveratrol causes cancerous cells to commit “cellular suicide” by actively inhibiting the cancerous cells ability to effectively use a protein called nuclear factor-kappa B (NF-kB).  NF-kB nourishes cancer cells, promoting their development and encouraging their spread.

Resveratrol is also showing promise in breast cancer prevention and treatment, though studies are still very much in their early stages.  Initial results look promising, as Resveratrol doesn’t seem to target a specific cancer type, rather the cancerous condition.

Click here to read the full article on examiner.com.

For over 250 years, those living in the southern US were enjoying what has been shown to be one of the most healthy substances around: Muscadines.  Muscadine grapes offer many of the same benefits that a “regular” grape does: great taste, a firm texture, and the ability to be made into wines, jellys, and jams.  However, the muscadines have been shown to contain up to seven times more Resveratrol in wine (up to 40mg/L) than “regular” wines.

In this article by “Georgia Faces”, the cancer-fighting properties of Resveratrol are mentioned, though very briefly.  Resveratrol has been shown to turn off the “defense mechanisms” of cancerous cells, making them vulnerable to your body’s natural defenses.

Muscadines are available in just about every grocery store, farmers market, and corner store in the southern US (and they are becoming increasingly popular in other areas of America as well).  If you’ve never tried one, perhaps now is the time to pick one up and see if you like it.

Click here to read the full article by Georgia Faces.

If we were talking about any other substance you would be able to call bogus on the title, but given that we’re talking about Resveratrol, anything is possible.  David Sinclair, a Harvard Medical School professor, is perhaps the biggest proponent in regards to Resveratrol- but he’s not the only one.  His recently-established pharmaceutical company, Sitris Pharmaceuticals, was purchased by GlaxoSmithKline for $720 million.  The reason?  Resveratrol.

According to Sinclair, scientists are already able to better the lives of laboratory animals significantly by giving them moderate doses of Resveratrol.  He, and a growing number of other scientists and medical professionals, believes that those same benefits can be transferred over to humans with little or no modifications required.  In other words, Resveratrol is starting to live up to its hype.

News such as this has spurred an explosion of Resveratrol-based supplement sales.  While David Sinclair has taken these supplements, he urges that it is not a replacement for exercise.

Click here to read the full article on ajc.com.

Resveratrol has been shown to stimulate the production of a protein, called adiponectin, that is known in its role in the prevention of obesity-related disorders, such as diabetes or clogged coronary arteries.  How exactly Resveratrol does this is still unknown, but it does inhibit the production of certain cytokines (interleukins 6 and 8)- two compounds that have been linked to the development of obesity-related disorders.

Researchers at the University of Ulm in Germany wanted to further explore Resveratrol’s role in healthy weight maintenance and loss, specifically targeting the question of whether or not Resveratrol could mimic its calorie-restrictive effects in human fat cells as it does in rats.

Pamela Fischer-Posovszky, a pediatric endocrinology research specialist at the university’s Diabetes and Obesity unit, noted that “Resveratrol has anti-obesity properties by exerting its effects directly on the fat cells.  Thus, Resveratrol might help to prevent development of obesity or might be suited to treating obesity.”  She also noted that volunteers who took a relatively large 5g dosage of Resveratrol (which is much higher than what is found in a bottle of red wine) did not experience any ill effects.

Read the full article at physorg.com.

Everyone’s stomach and digestive process is unique.  What bothers one person to the point of staying home is perfectly gentile to others.  This is true for many medications as well as a most food products.

Resveratrol is suggested to be taken on an empty stomach in between breakfast an lunch for maximum absorption rates.  If you are used to packing on bacon & hashbrowns for breakfast, there is a chance some grease still lingers around and, when mixed, will cause some stomach issues.

You know your body’s tolerances better than anyone else (likely including your doctor).  If resveratrol causes uneasiness in your stomach, change your regime around until you find a schedule for taking your supplement that fits you.

So, to answer the questions “does resveratrol cause diarrhea?” my answer would have to be … maybe :]

The news is abuzz with stories about Resveratrol, the “heart healthy” compound that is shaping up to be perhaps the single most important supplemental discovery of our time.  Unlike other “wonder drugs”, Resveratrol is quickly stacking up scientific evidence in its favor.  News-Medical.net recently talked about how Resveratrol is becoming the compound-du-jour.

Key points of their article noted that:

• Resveratrol is showing immense potential for cancer chemoprevention and cardioprotection.

• Signs that Resveratrol may aid in the prevention of age-related conditions, such as neuodegenerative diseases, inflammation, diabetes, and cardiovascular diseases.

• Low doses of Resveratrol improve cell survival and their active survival mechanisms in laboratory studies in rats.

Stephen Taylor, a professor of pharmacology at the University of Queensland, added that “most of the reseveratrol in imbibed red wine does not reach the circulation. Interestingly, absorption via the mucous membranes in the mouth can result in up to around 100 times the blood levels, if done slowly rather than simply gulping it down. Of course, we don’t know if these things matter yet, but issues like this are real and generally ignored by all.”

Read the full article on News-Medical.net.

Certain changes in DNA can cause normal breast cells to become cancerous. Doctors are searching for the answer as to what causes cancer (breast and other) today, but nobody is able to put their finger on it.  It’s widely accepted that resveratrol is not the underlying cause for cancer.

Resveratrol, a phytoestrogen found in grapes and red wine, is known to function as an estrogen receptor (ER) agonist, but whether it might also exert antagonist activity is controversial.  There is growing interest in phytoestrogens such as resveratrol as potential cancer chemopreventive agents.  Studies have shown the growth inhibiting tendencies of resveratrol when combating cancer cells, it also has tendencies slow the blood flow, therefore blocking regeneration.

From PubMed: “Resveratrol is considered a potential cancer chemopreventive agent. Resveratrol has been shown to induce transcription via both ERalpha and ERbeta. We observed significantly lower tumor growth, decreased angiogenesis, and increased apoptotic index in ERalpha- ERbeta+ MDA-MB-231 tumors in resveratrol-treated nude mice compared with controls. …  This study supports the potential use of resveratrol as a chemotherapeutic agent in breast cancers.”

So to answer your question in non-medical jargon, It is extremely unlikely that resveratrol is the cause for breast cancer.  It very likely is an inhibitor for the growth of cancer cells and therefore might be part of the solution.  If you currently have breast cancer, consult your doctor before taking resveratrol supplements.

Resveratrol itself is no more a scam than vitamin C or calcium. It is a substance found in nature that help protect fruits from bacteria and other invading elements. The “scam” angle the media has played on the public lately is due to the deceptive marketing and the rebill profit model that many companies have forced upon consumers.

Aside from that, resveratrol is sort of a wonder drug because it has a WIDE array of benefits (anti-aging >> weight loss >> cancer prevention >> diabetes) so it’s easy to see how people would be a bit skeptical. It recently became the latest “hype” by people attempting to make a quick buck since it’s gotten a ton of exposure from the likes of 20/20, CBS, Oprah & many others.

The truth is, resveratrol has been known about for some years now and the French have had relatively high amounts of resveratrol in their diet for generations. It’s definitely not a hoax or scam, but it’s not an overnight cure for anything. It does take the body some time to build up resveratrol levels … meaning the longer you take it, the healthier you’ll become.

The honest answer is that there’s not enough long term research in place to for me to tell you that any suppliment is safe for children. America’s laws prohibits the consumption of wine by minors which is the substance humans consume that has the most active ingredient. It’s probably best to give children a lot of grape juice and simply wait until their body has fully developed before introucing it to any dietary resveratrol suppliment.

Recently, Palsamy and Subramanian published articles on the antihyperglycemic potential of resveratrol in experimental diabetic rats. In their study, an oral administration of resveratrol was given to experimental diabetic rats for 30 days which significantly normalized the levels of blood glucose, plasma insulin, glycosylated hemoglobin, AST, ALP, ALT, and modulates the altered activities of carbohydrate metabolizing enzymes in the liver and kidney tissus of diabetic rats.

That’s the long way of saying \”yes\”, it appears that resveratrol can be used to help both type 1 & 2 diabetes patients. Obviously, don’t stop taking your insulin when you get your 1st shipment but keep an eye on your blood sugar and share results with your doctor.